Important Safety Information
Mechanism of Action
Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist that belongs to a class of drugs called incretin mimetics. Incretins are a type of hormone that stimulate a decrease in blood glucose levels, such as GLP-1 that binds to and activates the GLP-1 receptor. GLP-1 works to regulate ones appetite and caloric intake, and the GLP-1 receptor is present in several areas of your body, including areas in your brain responsible for appetite regulation. Semaglutide, as an agonist, binds to the GLP-1 receptor and works to lower blood glucose by stimulating insulin secretion and to inhibit glucagon release.
Adverse Reactions
Semaglutide is associated with GI adverse reactions, including nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, abdominal distention, eructation, flatulence, gastroenteritis, and gastroesophageal reflux disease. It has also been associated with causing headache, fatigue, dizziness, and hypoglycemia in patients with type 2 diabetes. Please discuss with your physician the contraindications and other warning and precautions before starting Semaglutide.
